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Target
Prostaglandin E synthase
Ligand
BDBM31129
Substrate
n/a
Meas. Tech.
ChEMBL_604678 (CHEMBL1068501)
IC50
600±n/a nM
Citation
 Koeberle, A; Haberl, EM; Rossi, A; Pergola, C; Dehm, F; Northoff, H; Troschuetz, R; Sautebin, L; Werz, O Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1. Bioorg Med Chem 17:7924-32 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM31129
Synonyms:
5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11h
Type:
Small organic molecule
Emp. Form.:
C23H21NO4
Mol. Mass.:
375.4171
SMILES:
CCOC(=O)c1c(Cc2cccc(OC)c2)[nH]c2c1cc(O)c1ccccc21
Structure:
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