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Target
Voltage-dependent calcium channel alpha-2 delta subunit
Ligand
BDBM50304704
Substrate
n/a
Meas. Tech.
ChEMBL_605546 (CHEMBL1067300)
IC50
1300±n/a nM
Citation
 Blakemore, DC; Bryans, JS; Carnell, P; Chessum, NE; Field, MJ; Kinsella, N; Kinsora, JK; Osborne, SA; Williams, SC Synthesis and in vivo evaluation of 3-substituted gababutins. Bioorg Med Chem Lett 20:362-5 (2010) [PubMed]  Article 
Target
Name:
Voltage-dependent calcium channel alpha-2 delta subunit
Synonyms:
Voltage-dependent calcium channel alpha2delta subunit
Type:
PROTEIN
Mol. Mass.:
123127.66
Organism:
Sus scrofa
Description:
ChEMBL_605546
Residue:
1091
Sequence:
MAAGCLLALTLTLFQSLLIGPSSQEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADILHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALEDYTDCGGVSGLNPSLWSIFGIQCVLLWLLSGSRHYQL
  
Inhibitor
Name:
BDBM50304704
Synonyms:
2-((3S)-1-(aminomethyl)-3-methylcyclopentyl)acetic acid | CHEMBL594443
Type:
Small organic molecule
Emp. Form.:
C9H17NO2
Mol. Mass.:
171.2368
SMILES:
C[C@H]1CCC(CN)(CC(O)=O)C1 |r|
Structure:
Search PDB for entries with ligand similarity: