Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50305059
Substrate
n/a
Meas. Tech.
ChEMBL_603036 (CHEMBL1047697)
IC50
3±n/a nM
Citation
 Bernotas, RCSinghaus, RRKaufman, DHTravins, JMUllrich, JWUnwalla, RQuinet, EEvans, MNambi, POlland, AKauppi, BWilhelmsson, AGoos-Nilsson, AWrobel, J 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists. Bioorg Med Chem Lett 20:209-12 (2010) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50305059
Synonyms:
4-(3-(3-chloro-5-(methylsulfonyl)phenoxy)phenyl)-3-methyl-8-(trifluoromethyl)quinoline | CHEMBL594176
Type:
Small organic molecule
Emp. Form.:
C24H17ClF3NO3S
Mol. Mass.:
491.91
SMILES:
Cc1cnc2c(cccc2c1-c1cccc(Oc2cc(Cl)cc(c2)S(C)(=O)=O)c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: