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Target
Neutrophil elastase
Ligand
BDBM50305812
Substrate
n/a
Meas. Tech.
ChEMBL_605043 (CHEMBL1071303)
IC50
>100000±n/a nM
Citation
 Xu, GH; Kim, YH; Chi, SW; Choo, SJ; Ryoo, IJ; Ahn, JS; Yoo, ID Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa. Bioorg Med Chem Lett 20:513-5 (2010) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50305812
Synonyms:
6-O-E-pcoumaroyl scandoside methyl ester | CHEMBL506966 | E-6-O-p-coumaroyl scandoside methyl ester
Type:
Small organic molecule
Emp. Form.:
C26H30O13
Mol. Mass.:
550.5086
SMILES:
COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]2[C@@H]1[C@H](OC(=O)\C=C\c1ccc(O)cc1)C=C2CO |r,c:38,t:4|
Structure:
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