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Target
Voltage-dependent calcium channel alpha-2 delta subunit
Ligand
BDBM50305895
Substrate
n/a
Meas. Tech.
ChEMBL_605315 (CHEMBL1071340)
IC50
2800±n/a nM
Citation
 Blakemore, DC; Bryans, JS; Carnell, P; Carr, CL; Chessum, NE; Field, MJ; Kinsella, N; Osborne, SA; Warren, AN; Williams, SC Synthesis and in vivo evaluation of bicyclic gababutins. Bioorg Med Chem Lett 20:461-4 (2010) [PubMed]  Article 
Target
Name:
Voltage-dependent calcium channel alpha-2 delta subunit
Synonyms:
Voltage-dependent calcium channel alpha2delta subunit
Type:
PROTEIN
Mol. Mass.:
123127.66
Organism:
Sus scrofa
Description:
ChEMBL_605546
Residue:
1091
Sequence:
MAAGCLLALTLTLFQSLLIGPSSQEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADILHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALEDYTDCGGVSGLNPSLWSIFGIQCVLLWLLSGSRHYQL
  
Inhibitor
Name:
BDBM50305895
Synonyms:
(+/-)-2-((6R)-6-(aminomethyl)bicyclo[3.2.0]heptan-6-yl)acetic acid | CHEMBL595758
Type:
Small organic molecule
Emp. Form.:
C10H17NO2
Mol. Mass.:
183.2475
SMILES:
NC[C@@]1(CC(O)=O)CC2CCCC12 |r|
Structure:
Search PDB for entries with ligand similarity: