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TargetLiver X receptor (LXR alpha AND LXR beta)
LigandBDBM50306079
Substrate/Competitorn/a
Meas. Tech.ChEMBL_605982
IC50 3.7±n/a nM
Citation Travins, JMBernotas, RCKaufman, DHQuinet, ENambi, PFeingold, IHuselton, CWilhelmsson, AGoos-Nilsson, AWrobel, J 1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists. Bioorg Med Chem Lett20:526-30 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Liver X receptor (LXR alpha AND LXR beta)
Name:Liver X receptor (LXR alpha AND LXR beta)
Synonyms:Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 | Oxysterols receptor LXR-alpha
Type:Receptor
Mol. Mass.:50403.85
Organism:Homo sapiens (Human)
Description:His-tagged hLXR.
Residue:447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM50306079
NameBDBM50306079
Synonyms:4-chloro-1-(2-chloro-5-(3-(methylsulfonyl)phenoxy)phenyl)-2-methyl-1H-benzo[d]imidazole | CHEMBL606143
TypeSmall organic molecule
Emp. Form.C21H16Cl2N2O3S
Mol. Mass.447.334
SMILESCc1nc2c(Cl)cccc2n1-c1cc(Oc2cccc(c2)S(C)(=O)=O)ccc1Cl |(26.98,-36.72,;25.44,-36.72,;24.53,-37.97,;23.07,-37.49,;21.74,-38.27,;21.74,-39.81,;20.4,-37.5,;20.41,-35.96,;21.73,-35.19,;23.07,-35.95,;24.53,-35.48,;24.52,-33.93,;25.85,-33.15,;25.84,-31.61,;27.16,-30.83,;28.5,-31.59,;28.51,-33.12,;29.85,-33.88,;31.17,-33.1,;31.16,-31.55,;29.82,-30.8,;32.48,-30.76,;33.8,-31.53,;33.56,-29.67,;31.38,-29.67,;24.49,-30.85,;23.16,-31.64,;23.18,-33.18,;21.86,-33.97,)|
Structure
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