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TargetLiver X receptor (LXR alpha AND LXR beta)
LigandBDBM50306081
Substrate/Competitorn/a
Meas. Tech.ChEMBL_605982
IC50 3.6±n/a nM
Citation Travins, JMBernotas, RCKaufman, DHQuinet, ENambi, PFeingold, IHuselton, CWilhelmsson, AGoos-Nilsson, AWrobel, J 1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists. Bioorg Med Chem Lett20:526-30 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Liver X receptor (LXR alpha AND LXR beta)
Name:Liver X receptor (LXR alpha AND LXR beta)
Synonyms:Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 | Oxysterols receptor LXR-alpha
Type:Receptor
Mol. Mass.:50403.85
Organism:Homo sapiens (Human)
Description:His-tagged hLXR.
Residue:447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM50306081
NameBDBM50306081
Synonyms:4-chloro-1-(2-chloro-5-(3-(isopropylsulfonyl)phenoxy)phenyl)-2-methyl-1H-benzo[d]imidazole | CHEMBL595454
TypeSmall organic molecule
Emp. Form.C23H20Cl2N2O3S
Mol. Mass.475.388
SMILESCC(C)S(=O)(=O)c1cccc(Oc2ccc(Cl)c(c2)-n2c(C)nc3c(Cl)cccc23)c1 |(17.87,-44.13,;16.53,-44.9,;16.53,-46.44,;15.21,-44.13,;16.29,-43.03,;14.11,-43.03,;13.89,-44.92,;13.91,-46.46,;12.58,-47.24,;11.24,-46.49,;11.23,-44.95,;9.89,-44.19,;8.57,-44.97,;7.22,-44.21,;5.88,-45.01,;5.9,-46.55,;4.58,-47.33,;7.24,-47.3,;8.58,-46.52,;7.26,-48.85,;8.17,-50.09,;9.7,-50.09,;7.26,-51.34,;5.79,-50.86,;4.46,-51.64,;4.47,-53.18,;3.13,-50.87,;3.13,-49.33,;4.46,-48.56,;5.79,-49.32,;12.55,-44.16,)|
Structure
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