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Target
Stearoyl-CoA desaturase
Ligand
BDBM50306114
Substrate
n/a
Meas. Tech.
ChEMBL_606060 (CHEMBL1071959)
IC50
0.56±n/a nM
Citation
 Uto, Y; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Ogata, T; Deguchi, T; Yamada, M; Watanabe, N; Konishi, M; Kurikawa, N; Takagi, T; Wakimoto, S; Kono, K; Ohsumi, J Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine]. Bioorg Med Chem Lett 20:746-54 (2010) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50306114
Synonyms:
CHEMBL594084 | N-(2-hydroxy-2-phenylethyl)-6-(3-hydroxyspiro[chroman-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C26H28N4O4
Mol. Mass.:
460.5249
SMILES:
OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)Oc1ccccc1CC2O)c1ccccc1
Structure:
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