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Target
Delta-type opioid receptor
Ligand
BDBM50306293
Substrate
n/a
Meas. Tech.
ChEMBL_607037 (CHEMBL1074665)
Ki
1.2±n/a nM
Citation
 Liras, S; McHardy, SF; Allen, MP; Segelstein, BE; Heck, SD; Bryce, DK; Schmidt, AW; Vanase-Frawley, M; Callegari, E; McLean, S Biaryl piperidines as potent and selective delta opioid receptor ligands. Bioorg Med Chem Lett 20:503-7 (2010) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50306293
Synonyms:
4-(1-((1H-imidazol-2-yl)methyl)-3-(3-hydroxyphenyl)piperidin-3-yl)-N,N-diethylbenzamide | CHEMBL605930
Type:
Small organic molecule
Emp. Form.:
C26H32N4O2
Mol. Mass.:
432.5579
SMILES:
CCN(CC)C(=O)c1ccc(cc1)C1(CCCN(Cc2ncc[nH]2)C1)c1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity: