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Target
D(1A) dopamine receptor
Ligand
BDBM50306329
Substrate
n/a
Meas. Tech.
ChEMBL_609554 (CHEMBL1073807)
Ki
4.7±n/a nM
Citation
 Qiang, L; Sasikumar, TK; Burnett, DA; Su, J; Tang, H; Ye, Y; Mazzola, RD; Zhu, Z; McKittrick, BA; Greenlee, WJ; Fawzi, A; Smith, M; Zhang, H; Lachowicz, JE Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists. Bioorg Med Chem Lett 20:836-40 (2010) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50306329
Synonyms:
CHEMBL604135 | N-((6aS,13bS)-11-chloro-12-hydroxy-7-methyl-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphtho[2,1-b]azepin-4-yl)methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C20H23ClN2O3S
Mol. Mass.:
406.926
SMILES:
CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(NS(C)(=O)=O)cccc21 |r|
Structure:
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