Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50306588
Substrate
n/a
Meas. Tech.
ChEMBL_610954 (CHEMBL1070285)
Ki
1.7±n/a nM
Citation
 Nugiel, DAKrumrine, JRHill, DCDamewood, JRBernstein, PRSobotka-Briner, CDLiu, JZacco, APierson, ME De novo design of a picomolar nonbasic 5-HT(1B) receptor antagonist. J Med Chem 53:1876-80 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50306588
Synonyms:
6-fluoro-8-(4-methylpiperazin-1-yl)-4-oxo-N-(4-(4-propionylpiperazin-1-yl)phenyl)-4H-chromene-2-carboxamide | AZD-1134 | CHEMBL602674
Type:
Small organic molecule
Emp. Form.:
C28H32FN5O4
Mol. Mass.:
521.5832
SMILES:
CCC(=O)N1CCN(CC1)c1ccc(NC(=O)c2cc(=O)c3cc(F)cc(N4CCN(C)CC4)c3o2)cc1
Structure:
Search PDB for entries with ligand similarity: