Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM50306654
Substrate
n/a
Meas. Tech.
ChEMBL_611257 (CHEMBL1068286)
IC50
83.8±n/a nM
Citation
 Kishore Kumar, GD; Chavarria, GE; Charlton-Sevcik, AK; Arispe, WM; Macdonough, MT; Strecker, TE; Chen, SE; Siim, BG; Chaplin, DJ; Trawick, ML; Pinney, KG Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorg Med Chem Lett 20:1415-9 (2010) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50306654
Synonyms:
CHEMBL601644 | [(3-Bromophenyl)-(2,3-difluorophenyl)-ketone]thiosemicarbazone
Type:
Small organic molecule
Emp. Form.:
C14H10BrF2N3S
Mol. Mass.:
370.215
SMILES:
NC(=S)NN=C(c1cccc(Br)c1)c1cccc(F)c1F |w:4.3|
Structure:
Search PDB for entries with ligand similarity: