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Target
Bile acid receptor
Ligand
BDBM50306718
Substrate
n/a
Meas. Tech.
ChEMBL_611889 (CHEMBL1070844)
EC50
190±n/a nM
Citation
 Lundquist, JT; Harnish, DC; Kim, CY; Mehlmann, JF; Unwalla, RJ; Phipps, KM; Crawley, ML; Commons, T; Green, DM; Xu, W; Hum, WT; Eta, JE; Feingold, I; Patel, V; Evans, MJ; Lai, K; Borges-Marcucci, L; Mahaney, PE; Wrobel, JE Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates. J Med Chem 53:1774-87 (2010) [PubMed]  Article 
Target
Name:
Bile acid receptor
Synonyms:
Bar | Farnesoid X-activated receptor | Farnesol receptor HRR-1 | Fxr | NR1H4_MOUSE | Nr1h4 | Nuclear receptor subfamily 1 group H member 4 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | Rip14
Type:
PROTEIN
Mol. Mass.:
55996.68
Organism:
Mus musculus
Description:
ChEMBL_793021
Residue:
488
Sequence:
MVMQFQGLENPIQISLHHSHRLSGFVPEGMSVKPAKGMLTEHAAGPLGQNLDLESYSPYNNVPFPQVQPQISSSSYYSNLGFYPQQPEDWYSPGIYELRRMPAETGYQGETEVSEMPVTKKPRMAAASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTANEDDSEGRDLRQVTSTTKFCREKTELTADQQTLLDYIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATSHVQILVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPAGHADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKMYQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
  
Inhibitor
Name:
BDBM50306718
Synonyms:
CHEMBL602894 | Isopropyl 1,1-Dimethyl-3-[4-(2-morpholin-4-ylethoxy)benzoyl]-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C31H37N3O5
Mol. Mass.:
531.6426
SMILES:
CC(C)OC(=O)C1=CN(CC(C)(C)c2c1[nH]c1ccccc21)C(=O)c1ccc(OCCN2CCOCC2)cc1 |t:6|
Structure:
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