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Target
Tyrosinase
Ligand
BDBM50240041
Substrate
n/a
Meas. Tech.
ChEMBL_609027 (CHEMBL1064494)
IC50
1800±n/a nM
Citation
 Thanigaimalai, P; Lee, KC; Bang, SC; Lee, JH; Yun, CY; Roh, E; Hwang, BY; Kim, Y; Jung, SH Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of alpha-MSH-induced melanin production in melanoma B16 cells. Bioorg Med Chem 18:1555-62 (2010) [PubMed]  Article 
Target
Name:
Tyrosinase
Synonyms:
LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB
Type:
Protein
Mol. Mass.:
60388.08
Organism:
Homo sapiens (Human)
Description:
P14679
Residue:
529
Sequence:
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
  
Inhibitor
Name:
BDBM50240041
Synonyms:
1-phenyl-2-thiourea | 1-phenylthiourea | CHEMBL263376 | N-Phenyl-thiourea | N-Phenylthiourea | phenylthiourea
Type:
Small organic molecule
Emp. Form.:
C7H8N2S
Mol. Mass.:
152.217
SMILES:
NC(=S)Nc1ccccc1
Structure:
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