Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 4
Ligand
BDBM50307044
Substrate
n/a
Meas. Tech.
ChEMBL_609338 (CHEMBL1072093)
IC50
420±n/a nM
Citation
 Li, G; Wang, D; Sun, M; Li, G; Hu, J; Zhang, Y; Yuan, Y; Ji, H; Chen, N; Liu, G Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice. J Med Chem 53:1741-54 (2010) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50307044
Synonyms:
8-Methyl-7-(4-methylpiperazin-1-yl)-6H-[1,3]dioxolo[4,5-g]-chromen-6-one | CHEMBL605581
Type:
Small organic molecule
Emp. Form.:
C16H18N2O4
Mol. Mass.:
302.3251
SMILES:
CN1CCN(CC1)c1c(C)c2cc3OCOc3cc2oc1=O
Structure:
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