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Target
Coagulation factor IX
Ligand
BDBM50307276
Substrate
n/a
Meas. Tech.
ChEMBL_610620 (CHEMBL1069634)
Ki
5±n/a nM
Citation
 Wang, S; Beck, R; Burd, A; Blench, T; Marlin, F; Ayele, T; Buxton, S; Dagostin, C; Malic, M; Joshi, R; Barry, J; Sajad, M; Cheung, C; Shaikh, S; Chahwala, S; Chander, C; Baumgartner, C; Holthoff, HP; Murray, E; Blackney, M; Giddings, A Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J Med Chem 53:1473-82 (2010) [PubMed]  Article 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM50307276
Synonyms:
(5-Ethylaminomethyl-1,3-dimethyl-1H-pyrazol-4-yl)-carbamic acid 2-(2-carbamimidoyl-benzo[b]thiophen-4-yloxy)-2-phenyl-ethyl ester | CHEMBL602082
Type:
Small organic molecule
Emp. Form.:
C25H28N6O3S
Mol. Mass.:
492.593
SMILES:
CNCc1c(NC(=O)OCC(Oc2cccc3sc(cc23)C(N)=N)c2ccccc2)c(C)nn1C
Structure:
Search PDB for entries with ligand similarity: