Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-2
Ligand
BDBM50307481
Substrate
n/a
Meas. Tech.
ChEMBL_611027 (CHEMBL1073016)
IC50
1800±n/a nM
Citation
 Geurink, PP; Liu, N; Spaans, MP; Downey, SL; van den Nieuwendijk, AM; van der Marel, GA; Kisselev, AF; Florea, BI; Overkleeft, HS Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites. J Med Chem 53:2319-23 (2010) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50307481
Synonyms:
(S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-3-phenylpropanamide | CHEMBL578478
Type:
Small organic molecule
Emp. Form.:
C36H42N6O5
Mol. Mass.:
638.7559
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)[C@@]1(C)CO1 |r|
Structure:
Search PDB for entries with ligand similarity: