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Target5-hydroxytryptamine receptor 2A
LigandBDBM50307812
Substrate/Competitorn/a
Meas. Tech.ChEMBL_612567
EC50 0.7±n/a nM
Citation Teegarden, BRLi, HJayakumar, HStrah-Pleynet, SDosa, PISelaya, SDKato, NElwell, KHDavidson, JCheng, KSaldana, HFrazer, JMWhelan, KFoster, JEspitia, SWebb, RRBeeley, NRThomsen, WMorairty, SRKilduff, TSAl-Shamma, HA Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia. J Med Chem53:1923-36 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 2A
Name:5-hydroxytryptamine receptor 2A
Synonyms:5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | HTR2 | HTR2A | Serotonin receptor 2A
Type:undefined
Mol. Mass.:52607.65
Organism:Homo sapiens (Human)
Description:P28223
Residue:471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50307812
NameBDBM50307812
Synonyms:1-[3-(4-Bromo-2-methyl-2Hpyrazol-3-yl)-4-methoxyphenyl]-3-(4-chlorophenyl)urea | CHEMBL591223
TypeSmall organic molecule
Emp. Form.C18H16BrClN4O2
Mol. Mass.435.702
SMILESCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C |(3.23,5.95,;3.24,4.41,;1.91,3.64,;.56,4.41,;-.76,3.63,;-.76,2.1,;-2.09,1.32,;-3.42,2.09,;-3.43,3.63,;-4.76,1.32,;-6.09,2.09,;-7.43,1.32,;-8.76,2.09,;-8.76,3.63,;-10.09,4.4,;-7.43,4.4,;-6.1,3.64,;.58,1.33,;1.91,2.1,;3.24,1.33,;3.4,-.2,;2.25,-1.22,;4.9,-.51,;5.67,.82,;4.64,1.96,;4.95,3.47,)|
Structure
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