Reaction Details Report a problem with these data
Target
Acetylcholinesterase
Ligand
BDBM50308418
Substrate
n/a
Meas. Tech.
ChEMBL_613958 (CHEMBL1068998)
Ki
810±n/a nM
Citation
Darvesh, S; Pottie, IR; Darvesh, KV; McDonald, RS; Walsh, R; Conrad, S; Penwell, A; Mataija, D; Martin, E Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem 18:2232-44 (2010) [PubMed] Article
More Info.:
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
Inhibitor
Name:
BDBM50308418
Synonyms:
CHEMBL605824 | N-[2-(N',N'-diisopropylamino)ethyl]-10H-phenothiazine-10-carboxamide, 4 | N-[2-(N',N'-Diisopropylamino)ethyl]-1'Hphenothiazine-1'-carboxamide
Type:
Small organic molecule
Emp. Form.:
C21H27N3OS
Mol. Mass.:
369.524
SMILES:
CC(C)N(CCNC(=O)N1c2ccccc2Sc2ccccc12)C(C)C