Reaction Details Report a problem with these data
Target
Carbonyl reductase [NADPH] 1
Ligand
BDBM50308751
Substrate
n/a
Meas. Tech.
ChEMBL_607771 (CHEMBL1068742)
IC50
13000±n/a nM
Citation
 Berhe, S; Slupe, A; Luster, C; Charlier, HA; Warner, DL; Zalkow, LH; Burgess, EM; Enwerem, NM; Bakare, O Synthesis of 3-[(N-carboalkoxy)ethylamino]-indazole-dione derivatives and their biological activities on human liver carbonyl reductase. Bioorg Med Chem 18:134-41 (2010) [PubMed]  Article 
Target
Name:
Carbonyl reductase [NADPH] 1
Synonyms:
CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1
Type:
PROTEIN
Mol. Mass.:
30380.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_607770
Residue:
277
Sequence:
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
  
Inhibitor
Name:
BDBM50308751
Synonyms:
3-(methyl-N-ethylcarbamate)-6-(N0-ethylphenylamino)indazol-4,7-dione | CHEMBL589095
Type:
Small organic molecule
Emp. Form.:
C19H20N4O4
Mol. Mass.:
368.3865
SMILES:
CCN(c1ccccc1)c1cc(O)c2c(CC=NC(=O)OC)n[nH]c2c1O |w:16.16|
Structure:
Search PDB for entries with ligand similarity: