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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50308852
Substrate
n/a
Meas. Tech.
ChEMBL_607677 (CHEMBL1071697)
Ki
65±n/a nM
Citation
 Combs, AP Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer. J Med Chem 53:2333-44 (2010) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50308852
Synonyms:
(S)-2-(N-(4-(2-acetamido-3-(4-(3-hydroxy-2-(methoxycarbonyl)phenoxy)butylamino)-3-oxopropyl)-2-ethylphenyl)-1-carboxyformamido)benzoic acid | CHEMBL590122
Type:
Small organic molecule
Emp. Form.:
C34H37N3O11
Mol. Mass.:
663.6711
SMILES:
CCc1cc(C[C@H](NC(C)=O)C(=O)NCCCCOc2cccc(O)c2C(=O)OC)ccc1N(C(=O)C(O)=O)c1ccccc1C(O)=O |r|
Structure:
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