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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50293594
Substrate
n/a
Meas. Tech.
ChEMBL_612215 (CHEMBL1074153)
IC50
10±n/a nM
Citation
 Tsukada, T; Takahashi, M; Takemoto, T; Kanno, O; Yamane, T; Kawamura, S; Nishi, T Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg Med Chem Lett 20:1004-7 (2010) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50293594
Synonyms:
5-(2-amino-5-isobutylthiazol-4-yl)furan-2-ylphosphonic acid | CHEMBL495498
Type:
Small organic molecule
Emp. Form.:
C11H15N2O4PS
Mol. Mass.:
302.287
SMILES:
CC(C)Cc1sc(N)nc1-c1ccc(o1)P(O)(O)=O
Structure:
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