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Target
Plasminogen activator inhibitor 1
Ligand
BDBM50310306
Substrate
n/a
Meas. Tech.
ChEMBL_607975 (CHEMBL1072391)
IC50
>300000±n/a nM
Citation
 El-Ayache, NC; Li, SH; Warnock, M; Lawrence, DA; Emal, CD Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1). Bioorg Med Chem Lett 20:966-70 (2010) [PubMed]  Article 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:
Enzyme
Mol. Mass.:
45064.00
Organism:
Homo sapiens (Human)
Description:
P05121
Residue:
402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
  
Inhibitor
Name:
BDBM50310306
Synonyms:
CHEMBL611972 | N,N'-(ethane-1,2-diyl)bis(N-ethylbenzenesulfonamide)
Type:
Small organic molecule
Emp. Form.:
C18H24N2O4S2
Mol. Mass.:
396.524
SMILES:
CCN(CCN(CC)S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Structure:
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