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Target
Antithrombin-III
Ligand
BDBM50310310
Substrate
n/a
Meas. Tech.
ChEMBL_607976 (CHEMBL1072392)
IC50
>300000±n/a nM
Citation
 El-Ayache, NC; Li, SH; Warnock, M; Lawrence, DA; Emal, CD Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1). Bioorg Med Chem Lett 20:966-70 (2010) [PubMed]  Article 
Target
Name:
Antithrombin-III
Synonyms:
ANT3_HUMAN | AT3 | ATIII | Antithrombin-III | Antithrombin-III precursor | Coagulation factor X/antithrombin III | SERPINC1
Type:
PROTEIN
Mol. Mass.:
52602.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_35871
Residue:
464
Sequence:
MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
  
Inhibitor
Name:
BDBM50310310
Synonyms:
CHEMBL596880 | N-benzyl-N-(3,4-dihydroxyphenylsulfonyl)-3,4-dihydroxybenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C19H17NO8S2
Mol. Mass.:
451.47
SMILES:
Oc1ccc(cc1O)S(=O)(=O)N(Cc1ccccc1)S(=O)(=O)c1ccc(O)c(O)c1
Structure:
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