Reaction Details Report a problem with these data
Target
Seminal ribonuclease
Ligand
BDBM50292723
Substrate
n/a
Meas. Tech.
ChEMBL_620093 (CHEMBL1109348)
pH
6±n/a
Ki
40800±n/a nM
Comments
extracted
Citation
 Dossi, K; Tsirkone, VG; Hayes, JM; Matousek, J; Poucková, P; Soucek, J; Zadinova, M; Zographos, SE; Leonidas, DD Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors. Eur J Med Chem 44:4496-508 (2009) [PubMed]  Article 
Target
Name:
Seminal ribonuclease
Synonyms:
RNS_BOVIN | SRN
Type:
PROTEIN
Mol. Mass.:
16390.13
Organism:
Bos taurus
Description:
ChEMBL_620093
Residue:
150
Sequence:
MALKSLVVLPLLVLVLLLVRVQPSLGKESAAAKFERQHMDSGNSPSSSSNYCNLMMCCRKMTQGKCKPVNTFVHESLADVKAVCSQKKVTCKNGQTNCYQSKSTMRITDCRETGSSKYPNCAYKTTQVEKHIIVACGGKPSVPVHFDASV
  
Inhibitor
Name:
BDBM50292723
Synonyms:
(2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate | CHEMBL447360 | PHOSPHORIC ACID MONO-[2-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-YL] ESTER | uridine 2'-phosphate
Type:
Small organic molecule
Emp. Form.:
C9H13N2O9P
Mol. Mass.:
324.1813
SMILES:
OC[C@H]1O[C@H]([C@H](OP(O)(O)=O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Structure:
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