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Target
72 kDa type IV collagenase
Ligand
BDBM50250808
Substrate
n/a
Meas. Tech.
ChEMBL_622215 (CHEMBL1106839)
IC50
10200±n/a nM
Citation
 Murata, T; Sasaki, K; Sato, K; Yoshizaki, F; Yamada, H; Mutoh, H; Umehara, K; Miyase, T; Warashina, T; Aoshima, H; Tabata, H; Matsubara, K Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum. J Nat Prod 72:1379-84 (2009) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa type IV collagenase | MMP2_RAT | Matrix metalloproteinase-2 (MMP-2) | Mmp2
Type:
n/a
Mol. Mass.:
74137.51
Organism:
Rattus norvegicus (Rat)
Description:
P33436
Residue:
662
Sequence:
MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM50250808
Synonyms:
CHEMBL518243 | lithospermic acid
Type:
Small organic molecule
Emp. Form.:
C27H22O12
Mol. Mass.:
538.4564
SMILES:
OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c2O[C@@H]([C@@H](C(O)=O)c12)c1ccc(O)c(O)c1 |r|
Structure:
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