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Target3-keto-steroid reductase
LigandBDBM50311131
Substrate/Competitorn/a
Meas. Tech.ChEMBL_619853
IC50 116±n/a nM
Citation Bellavance, ELuu-The, VPoirier, D Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. J Med Chem52:7488-502 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
3-keto-steroid reductase
Name:3-keto-steroid reductase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:38212.81
Organism:Homo sapiens (Human)
Description:ChEMBL_619853
Residue:341
Sequence:
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV
QVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTA
EGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFS
LEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIW
TLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQ
KMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50311131
NameBDBM50311131
Synonyms:(2'R,4aR,4bS,6aS,9aS,9bR,11aR)-1,4a,5',5',6a-pentamethylhexadecahydrospiro[indeno[5,4-f]quinoline-7,2'-pyran]-2,6'(1H,3'H)-dione | CHEMBL1078003
TypeSmall organic molecule
Emp. Form.C25H39NO3
Mol. Mass.401.5821
SMILESCN1[C@@H]2CC[C@H]3[C@@H]4CC[C@@]5(CCC(C)(C)C(=O)O5)[C@@]4(C)CC[C@@H]3[C@@]2(C)CCC1=O |r|
Structure
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n/a