Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Target3-keto-steroid reductase
LigandBDBM50311133
Substrate/Competitorn/a
Meas. Tech.ChEMBL_619853
IC50 189±n/a nM
Citation Bellavance, ELuu-The, VPoirier, D Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. J Med Chem52:7488-502 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
3-keto-steroid reductase
Name:3-keto-steroid reductase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:38212.81
Organism:Homo sapiens (Human)
Description:ChEMBL_619853
Residue:341
Sequence:
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV
QVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTA
EGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFS
LEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIW
TLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQ
KMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50311133
NameBDBM50311133
Synonyms:17beta-[(N-Heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one | CHEMBL1080041
TypeSmall organic molecule
Emp. Form.C27H48N2O
Mol. Mass.416.6828
SMILESCCCCCCCN(C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a