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TargetDeoxycytidine kinase
LigandBDBM50311540
Substrate/Competitorn/a
Meas. Tech.ChEMBL_618320
IC50>4000±n/a nM
Citation Tarver, JEJessop, TCCarlsen, MAugeri, DJFu, QHealy, JPHeim-Riether, AXu, ATaylor, JAShen, MKeyes, PEDavid Kimball, SYu, XCMiranda, MLiu, QSwaffield, JCNouraldeen, AWilson, AGFinch, RJhaver, KFoushee, AMAnderson, SOravecz, TCarson, KG 5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase. Bioorg Med Chem Lett19:6780-3 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Deoxycytidine kinase
Name:Deoxycytidine kinase
Synonyms:dCK
Type:PROTEIN
Mol. Mass.:30510.65
Organism:Homo sapiens (Human)
Description:ChEMBL_1437135
Residue:260
Sequence:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL
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  Blast E-value cutoff:
BDBM50311540
NameBDBM50311540
Synonyms:2'-deoxy-5-fluorocytidine | 4-amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | CHEMBL1076257
TypeSmall organic molecule
Emp. Form.C9H12FN3O4
Mol. Mass.245.2077
SMILESNc1nc(=O)n(cc1F)[C@H]1C[C@H](O)[C@@H](CO)O1 |r|
Structure
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n/a