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TargetDeoxycytidine kinase
LigandBDBM50311609
Substrate/Competitorn/a
Meas. Tech.ChEMBL_618643
EC50 90±n/a nM
Citation Jessop, TCTarver, JECarlsen, MXu, AHealy, JPHeim-Riether, AFu, QTaylor, JAAugeri, DJShen, MStouch, TRSwanson, RVTari, LWHunter, MHoffman, IKeyes, PEYu, XCMiranda, MLiu, QSwaffield, JCDavid Kimball, SNouraldeen, AWilson, AGFoushee, AMJhaver, KFinch, RAnderson, SOravecz, TCarson, KG Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett19:6784-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Deoxycytidine kinase
Name:Deoxycytidine kinase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:30361.42
Organism:Mus musculus
Description:ChEMBL_981695
Residue:260
Sequence:
MATPPKRFCPSPSTSSEGTRIKKISIEGNIAAGKSTFVNILKQASEDWEVVPEPVARWCN
VQSTQEEFEELTTSQKSGGNVLQMMYEKPERWSFTFQSYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNSQFGQSLELDGIIYLRA
TPEKCLNRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTSFDYLQEVPVLTLDVNE
DFKDKHESLVEKVKEFLSTL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50311609
NameBDBM50311609
Synonyms:CHEMBL1080444 | N-((1S,3S)-3-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)cyclopentyl)-4-(benzo[b]thiophen-2-yl)picolinamide
TypeSmall organic molecule
Emp. Form.C23H20FN5O2S
Mol. Mass.449.501
SMILESNc1nc(=O)n(cc1F)[C@H]1CC[C@@H](C1)NC(=O)c1cc(ccn1)-c1cc2ccccc2s1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a