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Target
Cyclin-dependent kinase 2
Ligand
BDBM50312757
Substrate
n/a
Meas. Tech.
ChEMBL_615646 (CHEMBL1104220)
IC50
19±n/a nM
Citation
 Zeng, Q; Bourbeau, MP; Wohlhieter, GE; Yao, G; Monenschein, H; Rider, JT; Lee, MR; Zhang, S; Lofgren, J; Freeman, D; Li, C; Tominey, E; Huang, X; Hoffman, D; Yamane, H; Tasker, AS; Dominguez, C; Viswanadhan, VN; Hungate, R; Zhang, X 2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics. Bioorg Med Chem Lett 20:1652-6 (2010) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50312757
Synonyms:
(S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)propane-1,2-diamine | CHEMBL1080913
Type:
Small organic molecule
Emp. Form.:
C19H18F2N6S
Mol. Mass.:
400.448
SMILES:
Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(F)c(F)c2)s1 |r|
Structure:
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