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Target
Histamine H2 receptor
Ligand
BDBM50312770
Substrate
n/a
Meas. Tech.
ChEMBL_615848 (CHEMBL1101958)
Ki
>10000±n/a nM
Citation
 Yu, M; Lizarzaburu, M; Beckmann, H; Connors, R; Dai, K; Haller, K; Li, C; Liang, L; Lindstrom, M; Ma, J; Motani, A; Wanska, M; Zhang, A; Li, L; Medina, JC Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity. Bioorg Med Chem Lett 20:1758-62 (2010) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50312770
Synonyms:
(4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-4-yl)methanone | CHEMBL1076586
Type:
Small organic molecule
Emp. Form.:
C26H23N3O2
Mol. Mass.:
409.4797
SMILES:
O=C(N1CCN(CC1)C(=O)c1ccc2cc[nH]c2c1)c1ccc(cc1)-c1ccccc1
Structure:
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