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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50313297
Substrate
n/a
Meas. Tech.
ChEMBL_617123 (CHEMBL1101381)
IC50
3±n/a nM
Citation
 Shah, U; Boyle, CD; Chackalamannil, S; Baker, H; Kowalski, T; Lee, J; Terracina, G; Zhang, L Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett 20:1551-4 (2010) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50313297
Synonyms:
(1R,5S)-3-(4-tert-butylphenylsulfonyl)-8-cyclopentyl-3,8-diazabicyclo[3.2.1]octane | CHEMBL1082165
Type:
Small organic molecule
Emp. Form.:
C21H32N2O2S
Mol. Mass.:
376.556
SMILES:
CC(C)(C)c1ccc(cc1)S(=O)(=O)N1C[C@@H]2CC[C@H](C1)N2C1CCCC1 |r,TLB:10:13:20:17.16|
Structure:
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