Reaction Details Report a problem with these data
Target
Glycylpeptide N-tetradecanoyltransferase 1
Ligand
BDBM50313452
Substrate
n/a
Meas. Tech.
ChEMBL_617371 (CHEMBL1101882)
IC50
8350000±n/a nM
Citation
 Jha, A; Mukherjee, C; Prasad, AK; Parmar, VS; Vadaparti, M; Das, U; De Clercq, E; Balzarini, J; Stables, JP; Shrivastav, A; Sharma, RK; Dimmock, JR Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore. Bioorg Med Chem Lett 20:1510-5 (2010) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM50313452
Synonyms:
(E)-4-oxo-4-(p-tolylamino)but-2-enoic acid | 4-oxo-4-(p-tolylamino)but-2-enoate | CHEMBL1084931
Type:
Small organic molecule
Emp. Form.:
C11H11NO3
Mol. Mass.:
205.2099
SMILES:
Cc1ccc(NC(=O)\C=C\C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: