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Target
Eukaryotic elongation factor 2 kinase
Ligand
BDBM50314416
Substrate
n/a
Meas. Tech.
ChEMBL_624587 (CHEMBL1111547)
IC50
1300±n/a nM
Citation
 Lockman, JW; Reeder, MD; Suzuki, K; Ostanin, K; Hoff, R; Bhoite, L; Austin, H; Baichwal, V; Adam Willardsen, J Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues. Bioorg Med Chem Lett 20:2283-6 (2010) [PubMed]  Article 
Target
Name:
Eukaryotic elongation factor 2 kinase
Synonyms:
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K
Type:
Protein
Mol. Mass.:
82116.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
725
Sequence:
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE
  
Inhibitor
Name:
BDBM50314416
Synonyms:
3-amino-4-(2-fluoro-5-methoxyphenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide | CHEMBL1090401
Type:
Small organic molecule
Emp. Form.:
C21H22FN3O2S
Mol. Mass.:
399.482
SMILES:
COc1ccc(F)c(c1)-c1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12 |(1.14,-33.78,;1.14,-35.32,;-.19,-36.08,;-1.53,-35.31,;-2.87,-36.09,;-2.86,-37.63,;-4.19,-38.41,;-1.53,-38.39,;-.19,-37.62,;-1.52,-39.93,;-2.85,-40.69,;-3.94,-39.6,;-5.48,-39.6,;-6.57,-40.69,;-6.57,-42.24,;-5.48,-43.32,;-3.94,-43.32,;-2.86,-42.24,;-1.53,-43.01,;-.2,-42.25,;1.28,-42.73,;2.2,-41.48,;3.74,-41.48,;4.51,-40.15,;4.5,-42.82,;1.29,-40.22,;1.77,-38.76,;-.19,-40.69,)|
Structure:
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