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Target
Eukaryotic elongation factor 2 kinase
Ligand
BDBM50314420
Substrate
n/a
Meas. Tech.
ChEMBL_624587 (CHEMBL1111547)
IC50
460±n/a nM
Citation
 Lockman, JW; Reeder, MD; Suzuki, K; Ostanin, K; Hoff, R; Bhoite, L; Austin, H; Baichwal, V; Adam Willardsen, J Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues. Bioorg Med Chem Lett 20:2283-6 (2010) [PubMed]  Article 
Target
Name:
Eukaryotic elongation factor 2 kinase
Synonyms:
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K
Type:
Protein
Mol. Mass.:
82116.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
725
Sequence:
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE
  
Inhibitor
Name:
BDBM50314420
Synonyms:
3-amino-4-(3-methylthiophen-2-yl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide | CHEMBL1091830
Type:
Small organic molecule
Emp. Form.:
C19H21N3OS2
Mol. Mass.:
371.52
SMILES:
Cc1ccsc1-c1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12 |(19.42,1.74,;17.96,2.21,;17.48,3.68,;15.94,3.68,;15.47,2.21,;16.72,1.31,;16.72,-.23,;15.39,-1,;14.31,.09,;12.76,.09,;11.67,-1,;11.67,-2.54,;12.77,-3.63,;14.31,-3.63,;15.39,-2.54,;16.72,-3.31,;18.05,-2.55,;19.53,-3.03,;20.44,-1.78,;21.98,-1.79,;22.76,-.45,;22.75,-3.12,;19.53,-.52,;20.01,.94,;18.05,-1,)|
Structure:
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