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TargetEukaryotic elongation factor 2 kinase
LigandBDBM50314422
Substrate/Competitorn/a
Meas. Tech.ChEMBL_624587
IC50 990±n/a nM
Citation Lockman, JWReeder, MDSuzuki, KOstanin, KHoff, RBhoite, LAustin, HBaichwal, VAdam Willardsen, J Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues. Bioorg Med Chem Lett20:2283-6 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Eukaryotic elongation factor 2 kinase
Name:Eukaryotic elongation factor 2 kinase
Synonyms:Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | eEF-2 kinase | eEF-2K
Type:Protein
Mol. Mass.:82116.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:725
Sequence:
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYY
SNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAV
TGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDV
YFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYN
SNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNL
GVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSP
QVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDN
MASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGR
VCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFC
EKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDY
LLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQ
DEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAW
AQMEE
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  Blast E-value cutoff:
BDBM50314422
NameBDBM50314422
Synonyms:3-amino-4-(1-methyl-1H-pyrrol-2-yl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide | CHEMBL1092378
TypeSmall organic molecule
Emp. Form.C19H22N4OS
Mol. Mass.354.469
SMILESCn1cccc1-c1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12 |(14.66,-10.94,;16.12,-10.46,;16.59,-8.99,;18.13,-8.99,;18.61,-10.46,;17.37,-11.36,;17.38,-12.9,;16.05,-13.67,;14.96,-12.58,;13.42,-12.58,;12.33,-13.67,;12.33,-15.21,;13.42,-16.3,;14.96,-16.3,;16.04,-15.21,;17.37,-15.98,;18.7,-15.22,;20.18,-15.7,;21.1,-14.45,;22.64,-14.46,;23.41,-13.12,;23.4,-15.79,;20.19,-13.19,;20.67,-11.73,;18.71,-13.67,)|
Structure
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n/a