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Target
Bombesin receptor subtype-3
Ligand
BDBM50314968
Substrate
n/a
Meas. Tech.
ChEMBL_627763 (CHEMBL1116185)
EC50
22±n/a nM
Citation
 Liu, J; He, S; Jian, T; Dobbelaar, PH; Sebhat, IK; Lin, LS; Goodman, A; Guo, C; Guzzo, PR; Hadden, M; Henderson, AJ; Pattamana, K; Ruenz, M; Sargent, BJ; Swenson, B; Yet, L; Tamvakopoulos, C; Peng, Q; Pan, J; Kan, Y; Palyha, O; Kelly, TM; Guan, XM; Howard, AD; Marsh, DJ; Metzger, JM; Reitman, ML; Wyvratt, MJ; Nargund, RP Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity. Bioorg Med Chem Lett 20:2074-7 (2010) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS3_MOUSE | Brs3
Type:
PROTEIN
Mol. Mass.:
44239.49
Organism:
Mus musculus
Description:
ChEMBL_1445902
Residue:
399
Sequence:
MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
  
Inhibitor
Name:
BDBM50314968
Synonyms:
2-(4-(2-(4-(cyclopentylmethyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridine | CHEMBL1091598
Type:
Small organic molecule
Emp. Form.:
C22H25N3
Mol. Mass.:
331.454
SMILES:
C(Cc1ccc(cc1)-c1ccccn1)c1ncc(CC2CCCC2)[nH]1
Structure:
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