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Target
Calcitonin gene-related peptide type 1 receptor
Ligand
BDBM50315399
Substrate
n/a
Meas. Tech.
ChEMBL_626018 (CHEMBL1106146)
IC50
4.7±n/a nM
Citation
 Stump, CA; Bell, IM; Bednar, RA; Fay, JF; Gallicchio, SN; Hershey, JC; Jelley, R; Kreatsoulas, C; Moore, EL; Mosser, SD; Quigley, AG; Roller, SA; Salvatore, CA; Sharik, SS; Theberge, CR; Zartman, CB; Kane, SA; Graham, SL; Selnick, HG; Vacca, JP; Williams, TM Identification of potent, highly constrained CGRP receptor antagonists. Bioorg Med Chem Lett 20:2572-6 (2010) [PubMed]  Article 
Target
Name:
Calcitonin gene-related peptide type 1 receptor
Synonyms:
Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52980.45
Organism:
Homo sapiens (Human)
Description:
Q16602
Residue:
461
Sequence:
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
  
Inhibitor
Name:
BDBM50315399
Synonyms:
(R)-2-((2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl)-6,8-dihydrospiro[cyclopenta[g]quinoline-7,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one | CHEMBL1090847
Type:
Small organic molecule
Emp. Form.:
C28H22N4O2
Mol. Mass.:
446.4999
SMILES:
O=C1Nc2ncccc2[C@]11Cc2cc3ccc(CN4C(=O)CCc5ccccc45)nc3cc2C1 |r|
Structure:
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