Reaction Details Report a problem with these data
Target
Cystine/glutamate transporter
Ligand
BDBM17663
Substrate
n/a
Meas. Tech.
ChEMBL_626785 (CHEMBL1107232)
IC50
26000±n/a nM
Citation
 Etoga, JL; Ahmed, SK; Patel, S; Bridges, RJ; Thompson, CM Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system x(c)(-) over the vesicular glutamate transporter. Bioorg Med Chem Lett 20:2680-3 (2010) [PubMed]  Article 
Target
Name:
Cystine/glutamate transporter
Synonyms:
SLC7A11 | XCT_HUMAN
Type:
PROTEIN
Mol. Mass.:
55437.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_772170
Residue:
501
Sequence:
MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQIILEVVPEEDKL
  
Inhibitor
Name:
BDBM17663
Synonyms:
(2S)-2-amino-3-(sulfooxy)propanoic acid | L-SOS | L-serine O-sulfate | Sulfoserine
Type:
Small organic molecule
Emp. Form.:
C3H7NO6S
Mol. Mass.:
185.156
SMILES:
N[C@@H](COS(O)(=O)=O)C(O)=O
Structure:
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