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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50315476
Substrate
n/a
Meas. Tech.
ChEMBL_626787 (CHEMBL1107234)
IC50
0.2±n/a nM
Citation
 Zhou, N; Polozov, AM; O'Connell, M; Burgeson, J; Yu, P; Zeller, W; Zhang, J; Onua, E; Ramirez, J; Palsdottir, GA; Halldorsdottir, GV; Andresson, T; Kiselyov, AS; Gurney, M; Singh, J 1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists. Bioorg Med Chem Lett 20:2658-64 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50315476
Synonyms:
3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)-N-(4-fluorophenylsulfonyl)acrylamide | CHEMBL1093239
Type:
Small organic molecule
Emp. Form.:
C24H15Cl2F3N2O4S
Mol. Mass.:
555.353
SMILES:
Fc1ccc(cc1)S(=O)(=O)NC(=O)\C=C\c1cccc2c1N(Cc1ccc(Cl)cc1Cl)C(=O)C2(F)F
Structure:
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