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TargetHuman diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)
LigandBDBM50315783
Substrate/Competitorn/a
Meas. Tech.ChEMBL_626085
Ki 1±n/a nM
Citation Penning, TDZhu, GDGong, JThomas, SGandhi, VBLiu, XShi, YKlinghofer, VJohnson, EFPark, CHFry, EHDonawho, CKFrost, DJBuchanan, FGBukofzer, GTRodriguez, LEBontcheva-Diaz, VBouska, JJOsterling, DJOlson, AMMarsh, KCLuo, YGiranda, VL Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. J Med Chem53:3142-53 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)
Name:PARP 1, 2 and 3
Synonyms:(ARTD2 or PARP2) | Poly [ADP-ribose] polymerase 2 | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) | Poly [ADP-ribose] polymerase 3 (PARP3)
Type:Enyme
Mol. Mass.:66225.70
Organism:Homo sapiens (Human)
Description:Q9UGN5
Residue:583
Sequence:
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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  Blast E-value cutoff:
BDBM50315783
NameBDBM50315783
Synonyms:2-(4-Piperidin-4-ylphenyl)-1H-benzimidazole-4-carboxamide | CHEMBL1090136
TypeSmall organic molecule
Emp. Form.C19H20N4O
Mol. Mass.320.3883
SMILESNC(=O)c1cccc2[nH]c(nc12)-c1ccc(cc1)C1CCNCC1
Structure
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n/a