Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50315814
Substrate
n/a
Meas. Tech.
ChEMBL_626103 (CHEMBL1111629)
EC50
1.8±n/a nM
Citation
 Hamada, M; Nakamura, M; Kiuchi, M; Marukawa, K; Tomatsu, A; Shimano, K; Sato, N; Sugahara, K; Asayama, M; Takagi, K; Adachi, K Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate. J Med Chem 53:3154-68 (2010) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM50315814
Synonyms:
2-Amino-4-[2'-fluoro-4'-(4-methylphenoxy)biphenyl-4-yl]-2-(phosphoryloxymethyl)butanol | CHEMBL1092284
Type:
Small organic molecule
Emp. Form.:
C24H28NO6P
Mol. Mass.:
457.456
SMILES:
Cc1ccc(Oc2ccc(cc2)-c2ccc(CCC(N)(CO)COP(O)(O)=O)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: