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Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM50241208
Substrate
n/a
Meas. Tech.
ChEMBL_624970 (CHEMBL1108826)
IC50
1800±n/a nM
Citation
 Hu, GX; Liang, G; Chu, Y; Li, X; Lian, QQ; Lin, H; He, Y; Huang, Y; Hardy, DO; Ge, RS Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg Med Chem Lett 20:2549-51 (2010) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
DHB3_RAT | Edh17b3 | Hsd17b3 | Testosterone 17-beta-dehydrogenase 3
Type:
PROTEIN
Mol. Mass.:
34235.73
Organism:
Rattus norvegicus
Description:
ChEMBL_1510493
Residue:
306
Sequence:
MEQFLLSVGLLVCLVCLVKCVRFSRYLFLSFCKALPGSFLRSMGQWAVITGAGDGIGKAYSFELARHGLNVVLISRTLEKLQVISEEIERTTGSRVKVVQADFTREDIYDHIEEQLKGLEIGVLVNNVGMLPNLLPSHFLSTSGESQSVIHCNITSVVKMTQLVLKHMESRRRGLILNISSGVGVRPWPLYSLYSASKAFVCTFSKALNVEYRDKGIIIQVLTPYSVSTPMTKYLNTSRVTKTADEFVKESLKYVTIGAETCGCLAHEILAIILNLIPSRIFYSSTTQRFLLKQFSDYLKSNISNR
  
Inhibitor
Name:
BDBM50241208
Synonyms:
(2E,6E)-2,6-bis(3,4,5-trimethoxybenzylidene)cyclohexanone | 2,6-Bis-(3,4,5-trimethoxy-benzylidene)-cyclohexanone | 2,6-bis((3,4,5-trimethoxyphenyl)methylene)-cyclohexanone | 2,6-bis(3,4,5-trimethoxybenzylidene)cyclohexanone | 2,6-bis-(3,4,5-trimethoxyphenylmethylene)-cyclohexanone | CHEMBL387599
Type:
Small organic molecule
Emp. Form.:
C26H30O7
Mol. Mass.:
454.5122
SMILES:
COc1cc(\C=C2/CCC\C(=C/c3cc(OC)c(OC)c(OC)c3)C2=O)cc(OC)c1OC
Structure:
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