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Target
Sterol O-acyltransferase 1
Ligand
BDBM50316163
Substrate
n/a
Meas. Tech.
ChEMBL_623543 (CHEMBL1117065)
IC50
>1000±n/a nM
Citation
 Asano, S; Ban, H; Tsuboya, N; Uno, S; Kino, K; Ioriya, K; Kitano, M; Ueno, Y A novel class of antihyperlipidemic agents with low density lipoprotein receptor up-regulation via the adaptor protein autosomal recessive hypercholesterolemia. J Med Chem 53:3284-95 (2010) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50316163
Synonyms:
2,6-Diisopropylphenyl{[4-(3-Methoxyphenyl)-1-phenylpiperidin-4-yl]carbonyl}sulfamate | CHEMBL1092671
Type:
Small organic molecule
Emp. Form.:
C31H38N2O5S
Mol. Mass.:
550.709
SMILES:
COc1cccc(c1)C1(CCN(CC1)c1ccccc1)C(=O)NS(=O)(=O)Oc1c(cccc1C(C)C)C(C)C
Structure:
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