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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50316306
Substrate
n/a
Meas. Tech.
ChEMBL_627828 (CHEMBL1117205)
Kd
2230±n/a nM
Citation
 Jia, Y; Chiu, TL; Amin, EA; Polunovsky, V; Bitterman, PB; Wagner, CR Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP. Eur J Med Chem 45:1304-13 (2010) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
Eif4e | IF4E_MOUSE
Type:
PROTEIN
Mol. Mass.:
25051.39
Organism:
Mus musculus
Description:
ChEMBL_627826
Residue:
217
Sequence:
MATVEPETTPTTNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50316306
Synonyms:
((2R,3S,4R,5R)-5-(2-Amino-7-(3-fluorobenzyl)-6-oxo-1Hpurin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylphosphate | CHEMBL1095619
Type:
Small organic molecule
Emp. Form.:
C17H19FN5O8P
Mol. Mass.:
471.3336
SMILES:
Nc1nc2n(c[n+](Cc3cccc(F)c3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r|
Structure:
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