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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50202829
Substrate
n/a
Meas. Tech.
ChEMBL_628629 (CHEMBL1106395)
IC50
371000±n/a nM
Citation
 Heng, S; Harris, KM; Kantrowitz, ER Designing inhibitors against fructose 1,6-bisphosphatase: exploring natural products for novel inhibitor scaffolds. Eur J Med Chem 45:1478-84 (2010) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_PIG | FBP | FBP1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36781.07
Organism:
Sus scrofa (Pig)
Description:
Liver FBPase (P00636)
Residue:
338
Sequence:
MTDQAAFDTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK
  
Inhibitor
Name:
BDBM50202829
Synonyms:
(+)-Usnic acid | 2,6-diacetyl-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bH)-one | CHEMBL242022 | NSC-685596 | Usninsaeure | usnein | usniacin | usnic acid | usninic acid
Type:
Small organic molecule
Emp. Form.:
C18H16O7
Mol. Mass.:
344.3154
SMILES:
CC(=O)C1=C(O)C=C2Oc3c(c(O)c(C)c(O)c3C(C)=O)[C@@]2(C)C1=O |r,c:3,t:6|
Structure:
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