Reaction Details Report a problem with these data
Target
Hyaluronidase-1
Ligand
BDBM50316415
Substrate
n/a
Meas. Tech.
ChEMBL_628271 (CHEMBL1111859)
IC50
102000±n/a nM
Citation
 Iwanaga, A; Kusano, G; Warashina, T; Miyase, T Phenolic constituents of the aerial parts of Cimicifuga simplex and Cimicifuga japonica. J Nat Prod 73:609-12 (2010) [PubMed]  Article 
Target
Name:
Hyaluronidase-1
Synonyms:
HYAL1 | HYAL1_HUMAN | Hyaluronidase | Hyaluronidase-1 | Hyaluronoglucosaminidase-1 | LUCA1
Type:
Protein
Mol. Mass.:
48369.09
Organism:
Homo sapiens (Human)
Description:
Q1279
Residue:
435
Sequence:
MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW
  
Inhibitor
Name:
BDBM50316415
Synonyms:
CHEMBL1097937 | Cimicifugic acid L | cimicifugic acid G
Type:
Small organic molecule
Emp. Form.:
C22H22O10
Mol. Mass.:
446.4041
SMILES:
COc1ccc(\C=C\C(=O)O[C@H](C(O)=O)[C@](O)(Cc2ccc(O)cc2)C(O)=O)cc1OC |r|
Structure:
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