Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAdenosine receptor A1
LigandBDBM50316881
Substrate/Competitorn/a
Meas. Tech.ChEMBL_629846
Ki 33.3±n/a nM
Citation Shook, BCRassnick, SChakravarty, DWallace, NAult, MCrooke, JBarbay, JKWang, ALeonard, KPowell, MTAlford, VHall, DRupert, KCHeintzelman, GRHansen, KBullington, JLScannevin, RHCarroll, KLampron, LWestover, LRussell, RBranum, SWells, KDamon, SYouells, SBeauchamp, DLi, XRhodes, KJackson, PF Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists. Bioorg Med Chem Lett20:2868-71 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adenosine receptor A1
Name:Adenosine receptor A1/Alpha-2A adrenergic receptor
Synonyms:A1 adenosine receptor (hA1) | A1AR | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:36520.92
Organism:Homo sapiens (Human)
Description:P30542
Residue:326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50316881
NameBDBM50316881
Synonyms:2-amino-8-(2-(dimethylamino)ethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | CHEMBL1088710
TypeSmall organic molecule
Emp. Form.C21H20N4O2
Mol. Mass.360.4091
SMILESCN(C)CCOc1ccc2C(=O)c3c(nc(N)nc3-c3ccccc3)-c2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a