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TargetAdenosine receptor A2a
LigandBDBM50316869
Substrate/Competitorn/a
Meas. Tech.ChEMBL_629845
Ki 12.4±n/a nM
Citation Shook, BCRassnick, SChakravarty, DWallace, NAult, MCrooke, JBarbay, JKWang, ALeonard, KPowell, MTAlford, VHall, DRupert, KCHeintzelman, GRHansen, KBullington, JLScannevin, RHCarroll, KLampron, LWestover, LRussell, RBranum, SWells, KDamon, SYouells, SBeauchamp, DLi, XRhodes, KJackson, PF Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists. Bioorg Med Chem Lett20:2868-71 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adenosine receptor A2a
Name:Adenosine receptor A2a
Synonyms:A2A adenosine receptor (hA2A) | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44716.46
Organism:Homo sapiens (Human)
Description:P29274
Residue:412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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  Blast E-value cutoff:
BDBM50316869
NameBDBM50316869
Synonyms:2-amino-N-(2-(dimethylamino)ethyl)-N-methyl-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxamide | CHEMBL1088259
TypeSmall organic molecule
Emp. Form.C23H23N5O2
Mol. Mass.401.461
SMILESCN(C)CCN(C)C(=O)c1ccc2C(=O)c3c(nc(N)nc3-c3ccccc3)-c2c1
Structure
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